論文 - 詳細
| RRC ID | 54974 |
|---|---|
| 著者 | Tabor KM, Smith TS, Brown M, Bergeron SA, Briggman KL, Burgess HA. |
| タイトル | Presynaptic Inhibition Selectively Gates Auditory Transmission to the Brainstem Startle Circuit. |
| ジャーナル | Curr Biol |
| Abstract |
Filtering mechanisms prevent a continuous stream of sensory information from swamping perception, leading to diminished focal attention and cognitive processing. Mechanisms for sensory gating are commonly studied using prepulse inhibition, a paradigm that measures the regulated transmission of auditory information to the startle circuit; however, the underlying neuronal pathways are unresolved. Using large-scale calcium imaging, optogenetics, and laser ablations, we reveal a cluster of 30 morphologically identified neurons in zebrafish that suppress the transmission of auditory signals during prepulse inhibition. These neurons project to a key sensorimotor interface in the startle circuit-the termination zone of auditory afferents on the dendrite of a startle command neuron. Direct measurement of auditory nerve neurotransmitter release revealed selective presynaptic inhibition of sensory transmission to the startle circuit, sparing signaling to other brain regions. Our results provide the first cellular resolution circuit for prepulse inhibition in a vertebrate, revealing a central role for presynaptic gating of sensory information to a brainstem motor circuit. |
| 巻・号 | 28(16) |
| ページ | 2527-2535.e8 |
| 公開日 | 2018-8-20 |
| DOI | 10.1016/j.cub.2018.06.020 |
| PII | S0960-9822(18)30811-X |
| PMID | 30078569 |
| PMC | PMC6410737 |
| MeSH | Animals Auditory Perception / physiology* Brain Stem / physiology Calcium / physiology Laser Therapy Neurons Optogenetics Prepulse Inhibition / physiology* Reflex, Startle / physiology Sensory Gating / physiology* Synaptic Transmission / physiology* Zebrafish / physiology* |
| IF | 9.193 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(gsx1:Cre) Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(vglut2a:|R|-Gal4) Tg(gad1b:|R|-GFP) Tg(glyt2:|R|-Gal4) Tg(huC:GVP) |