RRC ID 54974
Author Tabor KM, Smith TS, Brown M, Bergeron SA, Briggman KL, Burgess HA.
Title Presynaptic Inhibition Selectively Gates Auditory Transmission to the Brainstem Startle Circuit.
Journal Curr Biol
Abstract Filtering mechanisms prevent a continuous stream of sensory information from swamping perception, leading to diminished focal attention and cognitive processing. Mechanisms for sensory gating are commonly studied using prepulse inhibition, a paradigm that measures the regulated transmission of auditory information to the startle circuit; however, the underlying neuronal pathways are unresolved. Using large-scale calcium imaging, optogenetics, and laser ablations, we reveal a cluster of 30 morphologically identified neurons in zebrafish that suppress the transmission of auditory signals during prepulse inhibition. These neurons project to a key sensorimotor interface in the startle circuit-the termination zone of auditory afferents on the dendrite of a startle command neuron. Direct measurement of auditory nerve neurotransmitter release revealed selective presynaptic inhibition of sensory transmission to the startle circuit, sparing signaling to other brain regions. Our results provide the first cellular resolution circuit for prepulse inhibition in a vertebrate, revealing a central role for presynaptic gating of sensory information to a brainstem motor circuit.
Volume 28(16)
Pages 2527-2535.e8
Published 2018-8-20
DOI 10.1016/j.cub.2018.06.020
PII S0960-9822(18)30811-X
PMID 30078569
PMC PMC6410737
MeSH Animals Auditory Perception / physiology* Brain Stem / physiology Calcium / physiology Laser Therapy Neurons Optogenetics Prepulse Inhibition / physiology* Reflex, Startle / physiology Sensory Gating / physiology* Synaptic Transmission / physiology* Zebrafish / physiology*
IF 9.193
Times Cited 10
Zebrafish Tg(gsx1:Cre) Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(vglut2a:|R|-Gal4) Tg(gad1b:|R|-GFP) Tg(glyt2:|R|-Gal4) Tg(huC:GVP)