RRC ID 54987
Author Tsarouchas TM, Wehner D, Cavone L, Munir T, Keatinge M, Lambertus M, Underhill A, Barrett T, Kassapis E, Ogryzko N, Feng Y, van Ham TJ, Becker T, Becker CG.
Title Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.
Journal Nat Commun
Abstract neutrophils rescue functional regeneration in irf8 mutants. However, during early regeneration, interference with Il-1β function impairs regeneration in irf8 and wildtype animals. Hence, inflammation is dynamically controlled by macrophages to promote functional spinal cord regeneration in zebrafish.
Volume 9(1)
Pages 4670
Published 2018-11-7
DOI 10.1038/s41467-018-07036-w
PII 10.1038/s41467-018-07036-w
PMID 30405119
PMC PMC6220182
MeSH Animals Axons / metabolism Collagen Type XII / metabolism Inflammation Mediators / metabolism* Interleukin-1beta / metabolism* Macrophages / metabolism* Microglia / metabolism Microglia / pathology Mutation / genetics Nerve Regeneration* Neutrophils / metabolism Spinal Cord / metabolism* Spinal Cord / pathology Tumor Necrosis Factor-alpha / metabolism* Zebrafish / immunology Zebrafish / metabolism*
IF 12.353
Resource
Zebrafish Tg(6xTcf/LefBS-miniP:d2EGFP)