論文 - 詳細
| RRC ID | 55000 |
|---|---|
| 著者 | Juan T, Géminard C, Coutelis JB, Cerezo D, Polès S, Noselli S, Fürthauer M. |
| タイトル | Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. |
| ジャーナル | Nat Commun |
| Abstract |
The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry. |
| 巻・号 | 9(1) |
| ページ | 1942 |
| 公開日 | 2018-5-16 |
| DOI | 10.1038/s41467-018-04284-8 |
| PII | 10.1038/s41467-018-04284-8 |
| PMID | 29769531 |
| PMC | PMC5955935 |
| MeSH | Animals Animals, Genetically Modified Body Patterning / genetics* Cell Polarity / genetics Cilia / genetics Cilia / metabolism Embryo, Nonmammalian / embryology Embryo, Nonmammalian / metabolism Gene Expression Regulation, Developmental Left-Right Determination Factors / genetics Left-Right Determination Factors / metabolism Mutation Myosins / genetics* Myosins / metabolism Zebrafish / embryology Zebrafish / genetics* Zebrafish / metabolism Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism |
| IF | 11.878 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(sox17:EGFP) |