RRC ID 55011
Author Rulands S, Iglesias-Gonzalez AB, Boije H.
Title Deterministic fate assignment of Müller glia cells in the zebrafish retina suggests a clonal backbone during development.
Journal Eur J Neurosci
Abstract The optic cup houses multipotent retinal progenitor cells that proliferate and differentiate to form the mature retina, containing five main types of neurons and a single glial cell type, the Müller cell. Progenitors of the zebrafish optic cup generate clones that vary regarding the number and types of neurons, a process we previously showed could be described by stochastic models. Here, we present data indicating that each retinal progenitor cell, in the 24 hrs post-fertilization optic cup, is predestined to form a single Müller cell. This striking fate assignment of Müller cells reveals a dual nature of retinal lineages where stochastic mechanisms produce variable numbers of neurons while there is a strong deterministic component governing the formation of glia cells. A possible mechanism for this stereotypic fate assignment could be the maintenance of a clonal backbone during retina development, which would be similar to invertebrate and rodent cortical neurogenesis.
Volume 48(12)
Pages 3597-3605
Published 2018-12-1
DOI 10.1111/ejn.14257
PMID 30408243
PMC PMC6588021
MeSH Animals Animals, Genetically Modified / genetics Cell Differentiation / physiology Cell Proliferation / physiology Ependymoglial Cells / metabolism* Neurogenesis / physiology Neuroglia / metabolism* Neurons / metabolism Retina / metabolism* Stem Cells / metabolism* Zebrafish / metabolism Zebrafish Proteins / metabolism
IF 2.784
Times Cited 0
Zebrafish Tg(chx10:GFP)