| RRC ID |
55012
|
| 著者 |
Kawahara A, Morita H, Yanagi K, Suzuki H, Mori T, Ohga R, Taimatsu K.
|
| タイトル |
Spatiotemporal expression of the cocaine- and amphetamine-regulated transcript-like (cart-like) gene during zebrafish embryogenesis.
|
| ジャーナル |
Gene Expr Patterns
|
| Abstract |
The cocaine- and amphetamine-regulated transcript (CART) genes are involved in the neural regulation of energy homeostasis; however, their developmental expressions and functions are not fully understood in vertebrates. We have identified a novel zebrafish cart-like gene that encodes a protein of 105 amino acids possessing sequence similarity to zebrafish and mammalian CART proteins. RT-PCR analysis revealed that the cart-like transcripts were maternally supplied and gradually decreased during the cleavage, blastula and gastrula stages; then, transcripts subsequently reaccumulated at the segmentation, pharyngula and hatching stages. Based on a whole-mount in situ hybridization analysis using an antisense cart-like RNA probe, we found that the cart-like transcript was predominantly expressed in both the Rohon-Beard neurons and trigeminal ganglia, suggesting the involvement of the cart-like gene in zebrafish neural development.
|
| 巻・号 |
30
|
| ページ |
1-6
|
| 公開日 |
2018-12-1
|
| DOI |
10.1016/j.gep.2018.08.002
|
| PII |
S1567-133X(18)30068-1
|
| PMID |
30125742
|
| MeSH |
Amino Acid Sequence
Animals
Blastula / cytology
Blastula / metabolism
Embryo, Nonmammalian / cytology
Embryo, Nonmammalian / metabolism*
Embryonic Development
Gastrula / cytology
Gastrula / metabolism
Gene Expression Regulation, Developmental*
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Neurogenesis
Phylogeny
Sequence Homology
Spatio-Temporal Analysis
Zebrafish / embryology*
Zebrafish / genetics*
Zebrafish / metabolism
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism*
|
| IF |
1.154
|
| 引用数 |
0
|
| リソース情報 |
| ゼブラフィッシュ |
Tg (zCREST2-hsp70:GFP) |
