論文 - 詳細
| RRC ID | 55055 |
|---|---|
| 著者 | Kumar M, Mathur T, Joshi V, Upadhyay DJ, Inoue SI, Masuda N. |
| タイトル | Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota. |
| ジャーナル | Anaerobe |
| Abstract |
DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and monkeys. Considering the high activity of DS-2969b against Clostridium difficile, 10 μg/g of faecal levels would be sufficient for clearing C. difficile from the intestine. |
| 巻・号 | 51 |
| ページ | 120-123 |
| 公開日 | 2018-6-1 |
| DOI | 10.1016/j.anaerobe.2018.04.017 |
| PII | S1075-9964(18)30074-X |
| PMID | 29758524 |
| MeSH | Animals Bacterial Load Clostridioides difficile / drug effects DNA Gyrase / metabolism* Feces / microbiology Gastrointestinal Microbiome / drug effects* Haplorhini Rats Topoisomerase II Inhibitors / administration & dosage* |
| IF | 2.704 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1255 |