RRC ID 55083
Author Guo L, Chen X, Xu L, Xiao M, Lu L.
Title Enzymatic Synthesis of 6'-Sialyllactose, a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase from Bacteroides fragilis NCTC9343.
Journal Appl. Environ. Microbiol.
Abstract -α-sialidase BfGH33C synthesized 6'-sialyllactose in a simple step with high transglycosylation activity and strict regioselectivity. Additionally, it could utilize oligosialic acid, which was newly prepared in an easy, economical way to reduce the substrate cost, as a glycosyl donor. All the studies laid a foundation for the practical use of BfGH33C in large-scale synthesis of sialylated oligosaccharides in the future.
Volume 84(13)
Published 2018-7-1
DOI 10.1128/AEM.00071-18
PII AEM.00071-18
PMID 29678922
PMC PMC6007111
IF 3.633
Resource
General Microbes JCM 1254