論文 - 詳細
| RRC ID | 55165 |
|---|---|
| 著者 | Gao X, Mu P, Wen J, Sun Y, Chen Q, Deng Y. |
| タイトル | Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9. |
| ジャーナル | Food Chem Toxicol |
| Abstract |
Trichothecene mycotoxins are a group of structurally related sesquiterpenoid metabolites produced by multiple Fusarium species that often contaminate cereals and threaten human and animal health. The basic structure of this mycotoxin group is a characteristic 12, 13-epoxide group, which is considered an essential functional group for toxicity. In this study, using trichothecene mycotoxin deoxynivalenol (DON) as a representative substrate, we identified a novel trichothecene deepoxidation bacterium, Eggerthella sp. DII-9 (DII-9), from chicken intestines. DII-9 can grow and transform DON over abroad range of temperatures (20-45 °C) and pH values (5-10), suggesting the possibility of developing promising future applications as feed additives. Substrate specificity analysis showed that DII-9 is capable of promoting the deepoxidation of DON, HT-2, T-2 triol and T-2 tetraol. To explore the molecular mechanisms of the de-epoxidation of trichothecenes, the complete genome of DII-9 was sequenced and characterized. Altogether, a novel detoxification bacterium for trichothecene mycotoxins was identified and characterized. |
| 巻・号 | 112 |
| ページ | 310-319 |
| 公開日 | 2018-2-1 |
| DOI | 10.1016/j.fct.2017.12.066 |
| PII | S0278-6915(17)30816-5 |
| PMID | 29294345 |
| MeSH | Actinobacteria / classification Actinobacteria / genetics Actinobacteria / isolation & purification* Actinobacteria / metabolism* Animals Biodegradation, Environmental Chickens Intestines / microbiology* Mass Spectrometry Mycotoxins / chemistry Mycotoxins / metabolism* Phylogeny Trichothecenes / chemistry Trichothecenes / metabolism* |
| IF | 3.775 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 9979 |