論文 - 詳細
| RRC ID | 55193 |
|---|---|
| 著者 | Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara D. |
| タイトル | Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice. |
| ジャーナル | Int Immunopharmacol |
| Abstract |
Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma) is a strain of lactic acid bacteria (LAB) that activates murine and human plasmacytoid dendritic cells (pDCs) to express interferons (IFNs). Oral administration of LC-Plasma drastically decreased fatality levels caused by parainfluenza virus infection in a murine model. In this study, we investigated the anti-viral effects of oral administration of LC-Plasma using a suckling mouse model of rhesus rotavirus (RV) infection. LC-Plasma-fed mice showed improvement in retardation of body weight gain, fecal scores, and a reduction in RV titer in the feces when compared to control mice. The mechanism of anti-viral effects elicited by LC-Plasma administration was investigated using naive mice: in the LC-Plasma -fed mice, lamina propria (LP) pDCs resident in the small intestine were significantly matured and the proportion of pDCs was increased. The expression levels of anti-viral factors induced by IFNs, such as Isg15, Mx1, Oasl2 and Viperin, and an anti-bacterial factor Reg3γ, were up-regulated in the small intestinal epithelial cells (IECs) of LC-Plasma-fed mice. The specific LAB strain may affect the anti-viral immunological profile of IECs via maturation of LP pDCs, leading to protection from RV virus infection in vivo. |
| 巻・号 | 56 |
| ページ | 205-211 |
| 公開日 | 2018-3-1 |
| DOI | 10.1016/j.intimp.2018.01.034 |
| PII | S1567-5769(18)30034-1 |
| PMID | 29414652 |
| MeSH | Administration, Oral Animals Animals, Newborn Animals, Suckling Antiviral Agents / immunology* Cell Differentiation Cells, Cultured Dendritic Cells / microbiology Dendritic Cells / physiology* Epithelial Cells / physiology* Female Interferons / metabolism Lactococcus lactis / immunology* Mice Mice, Inbred BALB C Mucous Membrane / pathology* Pancreatitis-Associated Proteins / genetics Pancreatitis-Associated Proteins / metabolism Rotavirus / physiology* Rotavirus Infections / immunology* |
| IF | 3.361 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5805 |