RRC ID 55193
Author Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara D.
Title Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice.
Journal Int Immunopharmacol
Abstract Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma) is a strain of lactic acid bacteria (LAB) that activates murine and human plasmacytoid dendritic cells (pDCs) to express interferons (IFNs). Oral administration of LC-Plasma drastically decreased fatality levels caused by parainfluenza virus infection in a murine model. In this study, we investigated the anti-viral effects of oral administration of LC-Plasma using a suckling mouse model of rhesus rotavirus (RV) infection. LC-Plasma-fed mice showed improvement in retardation of body weight gain, fecal scores, and a reduction in RV titer in the feces when compared to control mice. The mechanism of anti-viral effects elicited by LC-Plasma administration was investigated using naive mice: in the LC-Plasma -fed mice, lamina propria (LP) pDCs resident in the small intestine were significantly matured and the proportion of pDCs was increased. The expression levels of anti-viral factors induced by IFNs, such as Isg15, Mx1, Oasl2 and Viperin, and an anti-bacterial factor Reg3γ, were up-regulated in the small intestinal epithelial cells (IECs) of LC-Plasma-fed mice. The specific LAB strain may affect the anti-viral immunological profile of IECs via maturation of LP pDCs, leading to protection from RV virus infection in vivo.
Volume 56
Pages 205-211
Published 2018-3-1
DOI 10.1016/j.intimp.2018.01.034
PII S1567-5769(18)30034-1
PMID 29414652
MeSH Administration, Oral Animals Animals, Newborn Animals, Suckling Antiviral Agents / immunology* Cell Differentiation Cells, Cultured Dendritic Cells / microbiology Dendritic Cells / physiology* Epithelial Cells / physiology* Female Interferons / metabolism Lactococcus lactis / immunology* Mice Mice, Inbred BALB C Mucous Membrane / pathology* Pancreatitis-Associated Proteins / genetics Pancreatitis-Associated Proteins / metabolism Rotavirus / physiology* Rotavirus Infections / immunology*
IF 3.361
Times Cited 4
General Microbes JCM 5805