| RRC ID |
55516
|
| 著者 |
Alshahni MM, Yamada T, Yo A, Murayama SY, Kuroda M, Hoshino Y, Ishikawa J, Watanabe S, Makimura K.
|
| タイトル |
Insight into the draft whole-genome sequence of the dermatophyte Arthroderma vanbreuseghemii.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Next-generation technologies have prompted efforts towards generating a large repertoire of whole-genome sequences. The dermatophyte Arthroderma vanbreuseghemii has been considered as a good model in which to conduct molecular biological studies on this fungal group. Despite the considerable repertoire of molecular tools developed for this fungus, the lack of genomic data has represented a major limitation, preventing effective implementation of those tools. Herein, the authors report the first draft whole-genome sequence of this dermatophytic species. The size of the draft genome was 23 Mb, exhibiting a GC content of 48.1%. Given the significance of secreted proteases in tissue invasion, a comparative analysis of genes encoding extracellular proteases was performed between A. vanbreuseghemii and other dermatophytes. Furthermore, genes that might be involved in DNA repair also were compared among dermatophytes. Moreover, the complete mitochondrial genome of A. vanbreuseghemii was obtained and shown to consist of 24,287 bp with a GC content of 24%. In conclusion, the availability of genomic data for A. vanbreuseghemii is expected to facilitate the implementation of the molecular tools established for this fungus, enhancing our understanding of the biology of dermatophytes.
|
| 巻・号 |
8(1)
|
| ページ |
15127
|
| 公開日 |
2018-10-11
|
| DOI |
10.1038/s41598-018-33505-9
|
| PII |
10.1038/s41598-018-33505-9
|
| PMID |
30310114
|
| PMC |
PMC6181936
|
| MeSH |
Arthrodermataceae / classification
Arthrodermataceae / genetics*
Base Composition
DNA Repair
Evolution, Molecular
Genome Size
Genome, Fungal*
Genomics* / methods
Phylogeny
Sequence Analysis, DNA
Whole Genome Sequencing
|
| IF |
4.011
|
| 引用数 |
1
|
| リソース情報 |
| 一般微生物 |
JCM 1891 |
