| RRC ID |
55747
|
| 著者 |
Higo N, Sato A, Yamamoto T, Oishi T, Nishimura Y, Murata Y, Onoe H, Isa T, Kojima T.
|
| タイトル |
Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury.
|
| ジャーナル |
J Comp Neurol
|
| Abstract |
The present study aimed to assess the molecular bases of cortical compensatory mechanisms following spinal cord injury in primates. To accomplish this, comprehensive changes in gene expression were investigated in the bilateral primary motor cortex (M1), dorsal premotor cortex (PMd), and ventral premotor cortex (PMv) after a unilateral lesion of the lateral corticospinal tract (l-CST). At 2 weeks after the lesion, a large number of genes exhibited altered expression levels in the contralesional M1, which is directly linked to the lesioned l-CST. Gene ontology and network analyses indicated that these changes in gene expression are involved in the atrophy and plasticity changes observed in neurons. Orchestrated gene expression changes were present when behavioral recovery was attained 3 months after the lesion, particularly among the bilateral premotor areas, and a large number of these genes are involved in plasticity. Moreover, several genes abundantly expressed in M1 of intact monkeys were upregulated in both the PMd and PMv after the l-CST lesion. These area-specific and time-dependent changes in gene expression may underlie the molecular mechanisms of functional recovery following a lesion of the l-CST.
|
| 巻・号 |
526(7)
|
| ページ |
1110-1130
|
| 公開日 |
2018-5-1
|
| DOI |
10.1002/cne.24396
|
| PMID |
29355954
|
| MeSH |
Animals
Animals, Newborn
Disease Models, Animal
Functional Laterality
Gene Expression / physiology*
Gene Ontology
Gene Regulatory Networks
Macaca mulatta
Microarray Analysis
Motor Cortex / metabolism*
Motor Cortex / physiopathology*
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism
Recovery of Function / physiology*
Spinal Cord Injuries / pathology*
Spinal Cord Injuries / physiopathology*
Time Factors
|
| IF |
3.4
|
| 引用数 |
2
|
| リソース情報 |
| ニホンザル |
|
