Reference - Detail
| RRC ID | 55777 |
|---|---|
| Author | Serikawa T, Kunisawa N, Shimizu S, Kato M, Alves Iha H, Kinboshi M, Nishikawa H, Shirakawa Y, Voigt B, Nakanishi S, Kuramoto T, Kaneko T, Yamamoto T, Mashimo T, Sasa M, Ohno Y. |
| Title | Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats. |
| Journal | Behav Brain Res |
| Abstract |
Phf24 is known as Gαi-interacting protein (GINIP) and is associated with the GABAB receptor. To study the function of Phf24 protein in the central nervous system (CNS), we have newly developed Phf24-null rats and investigated their behavioral phenotypes, especially changes in seizure sensitivity, emotional responses and cognitive functions. Phf24-null rats did not exhibit any spontaneous seizures. However, they showed a higher sensitivity to pentylenetetrazol (PTZ)- or pilocarpine-induced convulsive seizures. Phf24-null rats also showed an elevated susceptibility to kindling development with repeated PTZ treatments, suggesting that Phf24 acts as an inhibitory modulator in epileptogenesis. Although young Phf24-null rats showed normal gross behaviors, elevated spontaneous locomotor activity, especially in terms of the circadian dark period, emotional hyper-reactivity, reduced anxiety behaviors in the elevated plus-maze (EPM) test, and cognitive deficits in the Morris water maze test were explicitly observed at older age (20-week-old). The present results suggest that Phf24 is essential for proper functioning of the CNS, especially in preventing epileptogenesis and controlling emotional and cognitive functions. |
| Volume | 369 |
| Pages | 111922 |
| Published | 2019-9-2 |
| DOI | 10.1016/j.bbr.2019.111922 |
| PII | S0166-4328(19)30136-6 |
| PMID | 31039378 |
| MeSH | Animals Central Nervous System / metabolism Cognition / physiology Cognition Disorders / genetics Cognitive Dysfunction / genetics* Cognitive Dysfunction / metabolism Emotions / physiology Gene Knockout Techniques / methods Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Kindling, Neurologic / physiology Male Maze Learning / physiology PHD Zinc Fingers / genetics Rats Rats, Inbred F344 Receptors, GABA-B / genetics Seizures / etiology* Seizures / genetics Seizures / metabolism |
| IF | 2.77 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Rats | F344/Stm (strainID=266) |