Reference - Detail
| RRC ID | 55778 |
|---|---|
| Author | Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Suzuki J, Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. |
| Title | Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model. |
| Journal | Neuroscience |
| Abstract |
Cerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood-brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atrophy. Moreover, deterioration of amyloid-β (Aβ) clearance due to the failure of the transvascular BBB transport system results in accumulation of Aβ in the brain. Intravenous infusion of mesenchymal stem cells (MSCs) elicits functional recovery in experimental models including stroke and spinal cord injury. One effect of MSCs is to restore disrupted BBB through remodeling of microvasculature. Using spontaneously hypertensive rats (stroke-prone) with impaired cognitive function as a CSVD model, we have shown that infused MSCs has a therapeutic effect for cognitive function. Restoration of BBB function via remodeling of microvasculature and inhibition of Aβ accumulation could inhibit progressive brain atrophy and lead to restore cognitive dysfunction. Gene expression analysis indicated that infused MSCs activates both transforming growth factor-β and angiopoietin 1 signaling pathways and promotes the remodeling of microvasculature. Thus, infused MSCs may represent a novel therapy for both VD and AD. |
| Volume | 408 |
| Pages | 361-377 |
| Published | 2019-6-1 |
| DOI | 10.1016/j.neuroscience.2019.04.018 |
| PII | S0306-4522(19)30258-1 |
| PMID | 30999031 |
| MeSH | Animals Behavior, Animal / physiology Blood-Brain Barrier / pathology Cerebral Small Vessel Diseases / complications* Cerebral Small Vessel Diseases / pathology Cognition / physiology* Cognitive Dysfunction / etiology Cognitive Dysfunction / pathology Cognitive Dysfunction / therapy* Disease Models, Animal Infusions, Intravenous Mesenchymal Stem Cell Transplantation* Mesenchymal Stem Cells Rats Rats, Inbred SHR Recognition, Psychology / physiology* |
| IF | 3.244 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 6.0 |
| Resource | |
| Rats | W-Tg(CAG-GFP)184Ys (strainID=525) |