RRC ID |
55786
|
Author |
Mori J, Tang H, Kawabata A, Koike M, Mori Y.
|
Title |
Human Herpesvirus 6A U14 Is Important for Virus Maturation.
|
Journal |
J Virol
|
Abstract |
Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
|
Volume |
90(3)
|
Pages |
1677-81
|
Published |
2015-11-11
|
DOI |
10.1128/JVI.02492-15
|
PII |
JVI.02492-15
|
PMID |
26559847
|
PMC |
PMC4719638
|
MeSH |
Cells, Cultured
Herpesvirus 6, Human / genetics
Herpesvirus 6, Human / physiology*
Humans
Leukocytes, Mononuclear / virology
Mutant Proteins / genetics
Mutant Proteins / metabolism
Viral Structural Proteins / genetics
Viral Structural Proteins / metabolism*
Virus Replication*
|
IF |
4.324
|
Times Cited |
4
|
Resource |
Cord blood stem cells for research |
|