RRC ID 55803
Author Durcik M, Tammela P, Barančoková M, Tomašič T, Ilaš J, Kikelj D, Zidar N.
Title Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.
Journal ChemMedChem
Abstract of 47 nm against E. coli DNA gyrase, and a minimum inhibitory concentration (MIC) of 12.5 μm against the Gram-positive Enterococcus faecalis. Some compounds displayed good antibacterial activities against an efflux-pump-deficient E. coli strain (MIC=6.25 μm) and against wild-type E. coli in the presence of efflux pump inhibitor PAβN (MIC=3.13 μm). Here we describe new findings regarding the structure-activity relationships of N-phenylpyrrolamide DNA gyrase B inhibitors and investigate the factors that are important for the antibacterial activity of this class of compounds.
Volume 13(2)
Pages 186-198
Published 2018-1-22
DOI 10.1002/cmdc.201700549
PMID 29206345
IF 3.009
Resource
Prokaryotes E. coli JW5503, JD17464