論文 - 詳細
| RRC ID | 55867 |
|---|---|
| 著者 | Chew YL, Tanizawa Y, Cho Y, Zhao B, Yu AJ, Ardiel EL, Rabinowitch I, Bai J, Rankin CH, Lu H, Beets I, Schafer WR. |
| タイトル | An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans. |
| ジャーナル | Neuron |
| Abstract |
Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal sensitization is an important feature of arousal in many organisms, yet its molecular and neural mechanisms are incompletely understood. Here we show that in C. elegans, aversive mechanical stimuli lead to both enhanced locomotor activity and sensitization of aversive chemosensory pathways. Both locomotor arousal and cross-modal sensitization depend on the release of FLP-20 neuropeptides from primary mechanosensory neurons and on their receptor FRPR-3. Surprisingly, the critical site of action of FRPR-3 for both sensory and locomotor arousal is RID, a single neuroendocrine cell specialized for the release of neuropeptides that responds to mechanical stimuli in a FLP-20-dependent manner. Thus, FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states. |
| 巻・号 | 99(6) |
| ページ | 1233-1246.e6 |
| 公開日 | 2018-9-19 |
| DOI | 10.1016/j.neuron.2018.08.003 |
| PII | S0896-6273(18)30676-7 |
| PMID | 30146306 |
| PMC | PMC6162336 |
| MeSH | Animals Arousal / physiology* Behavior, Animal / physiology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism Central Nervous System / metabolism Locomotion / physiology* Neurons / physiology Neuropeptides / metabolism* Peptides / metabolism |
| IF | 14.403 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1583 tm1504 tm1325 tm1846 tm2913 tm1553 tm1568 tm1498 tm2706 |