RRC ID 55885
Author Heestand B, Simon M, Frenk S, Titov D, Ahmed S.
Title Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause.
Journal Cell Rep
Abstract Environmental stress can induce adult reproductive diapause, a state of developmental arrest that temporarily suspends reproduction. Deficiency for C. elegans Piwi protein PRG-1 results in strains that reproduce for many generations but then become sterile. We found that sterile-generation prg-1/Piwi mutants typically displayed pronounced germ cell atrophy as L4 larvae matured into 1-day-old adults. Atrophied germlines spontaneously reproliferated across the first days of adulthood, and this was accompanied by fertility for day 2-4 adults. Sterile day 5 prg-1 mutant adults remained sterile indefinitely, but providing an alternative food source could restore their fertility. Our data imply that late-generation prg-1 mutants experience a dynamic form of adult reproductive diapause, promoted by stress response, cell death, and RNAi pathways, where delayed fertility and reproductive quiescence represent parallel adaptive developmental outcomes. This may occur in response to a form of "heritable stress" that is transmitted by gametes and epigenetic in nature.
Volume 23(1)
Pages 156-171
Published 2018-4-3
DOI 10.1016/j.celrep.2018.03.015
PII S2211-1247(18)30344-9
PMID 29617657
PMC PMC5918633
MeSH Animals Argonaute Proteins / genetics* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Diapause* Epigenesis, Genetic* Fertility* Gametogenesis Germ Cells / cytology Germ Cells / metabolism Stress, Physiological
IF 7.815
Times Cited 9
C.elegans tm872 tm876