論文 - 詳細
| RRC ID | 56044 |
|---|---|
| 著者 | Aota K, Yamanoi T, Kani K, Azuma M. |
| タイトル | Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells. |
| ジャーナル | Inflammation |
| Abstract |
Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production. |
| 巻・号 | 41(1) |
| ページ | 50-58 |
| 公開日 | 2018-2-1 |
| DOI | 10.1007/s10753-017-0662-x |
| PII | 10.1007/s10753-017-0662-x |
| PMID | 28879548 |
| MeSH | Anti-Inflammatory Agents / pharmacology* Benzylisoquinolines / pharmacology* Chemokine CXCL10 / metabolism* Chemotaxis, Leukocyte / drug effects Dose-Response Relationship, Drug Humans Interferon-gamma / pharmacology* Janus Kinase 2 / metabolism* Jurkat Cells NF-kappa B / metabolism Phosphorylation STAT1 Transcription Factor / metabolism* Salivary Ducts / drug effects* Salivary Ducts / metabolism Signal Transduction / drug effects Time Factors |
| IF | 2.939 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Jurkat |