RRC ID |
56112
|
著者 |
El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S.
|
タイトル |
New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella.
|
ジャーナル |
Fitoterapia
|
Abstract |
New sipholane type triterpenes, sipholenols N and O (1 and 2) and neviotine D (3), were isolated from the Red Sea marine sponge Siphonochalina siphonella along with four known triterpenes, sipholenone A (4), sipholenol A (5), siphonellinol D (6) and neviotine A (7). Structure elucidation of 1-3 was achieved by extensive 1D and 2D NMR analyses. The isolated compounds were examined for the inhibition of RANKL induced osteoclastogenesis in RAW264 macrophages. Neviotine D (3) and neviotine A (4) showed potent inhibition with IC50 values of 12.8 and 32.8 μM, respectively.
|
巻・号 |
128
|
ページ |
43-49
|
公開日 |
2018-7-1
|
DOI |
10.1016/j.fitote.2018.05.001
|
PII |
S0367-326X(18)30500-8
|
PMID |
29729401
|
MeSH |
Animals
Callyspongia / chemistry*
Indian Ocean
Mice
Molecular Structure
Osteogenesis / drug effects*
RANK Ligand
RAW 264.7 Cells
Triterpenes / pharmacology*
|
IF |
2.431
|
引用数 |
4
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |