RRC ID 56112
Author El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S.
Title New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella.
Journal Fitoterapia
Abstract New sipholane type triterpenes, sipholenols N and O (1 and 2) and neviotine D (3), were isolated from the Red Sea marine sponge Siphonochalina siphonella along with four known triterpenes, sipholenone A (4), sipholenol A (5), siphonellinol D (6) and neviotine A (7). Structure elucidation of 1-3 was achieved by extensive 1D and 2D NMR analyses. The isolated compounds were examined for the inhibition of RANKL induced osteoclastogenesis in RAW264 macrophages. Neviotine D (3) and neviotine A (4) showed potent inhibition with IC50 values of 12.8 and 32.8 μM, respectively.
Volume 128
Pages 43-49
Published 2018-7-1
DOI 10.1016/j.fitote.2018.05.001
PII S0367-326X(18)30500-8
PMID 29729401
MeSH Animals Callyspongia / chemistry* Indian Ocean Mice Molecular Structure Osteogenesis / drug effects* RANK Ligand RAW 264.7 Cells Triterpenes / pharmacology*
IF 2.431
Times Cited 4
Human and Animal Cells RAW 264(RCB0535)