論文 - 詳細
| RRC ID | 56112 |
|---|---|
| 著者 | El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S. |
| タイトル | New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella. |
| ジャーナル | Fitoterapia |
| Abstract |
New sipholane type triterpenes, sipholenols N and O (1 and 2) and neviotine D (3), were isolated from the Red Sea marine sponge Siphonochalina siphonella along with four known triterpenes, sipholenone A (4), sipholenol A (5), siphonellinol D (6) and neviotine A (7). Structure elucidation of 1-3 was achieved by extensive 1D and 2D NMR analyses. The isolated compounds were examined for the inhibition of RANKL induced osteoclastogenesis in RAW264 macrophages. Neviotine D (3) and neviotine A (4) showed potent inhibition with IC50 values of 12.8 and 32.8 μM, respectively. |
| 巻・号 | 128 |
| ページ | 43-49 |
| 公開日 | 2018-7-1 |
| DOI | 10.1016/j.fitote.2018.05.001 |
| PII | S0367-326X(18)30500-8 |
| PMID | 29729401 |
| MeSH | Animals Callyspongia / chemistry* Indian Ocean Mice Molecular Structure Osteogenesis / drug effects* RANK Ligand RAW 264.7 Cells Triterpenes / pharmacology* |
| IF | 2.431 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |