RRC ID 56169
Author Hilbert ZA, Kim DH.
Title PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
Journal Elife
Abstract Sexually dimorphic behaviors are a feature common to species across the animal kingdom, however how such behaviors are generated from mostly sex-shared nervous systems is not well understood. Building on our previous work which described the sexually dimorphic expression of a neuroendocrine ligand, DAF-7, and its role in behavioral decision-making in C. elegans (Hilbert and Kim, 2017), we show here that sex-specific expression of daf-7 is regulated by another neuroendocrine ligand, Pigment Dispersing Factor (PDF-1), which has previously been implicated in regulating male-specific behavior (Barrios et al., 2012). Our analysis revealed that PDF-1 signaling acts sex- and cell-specifically in the ASJ neurons to regulate the expression of daf-7, and we show that differences in PDFR-1 receptor activity account for the sex-specific effects of this pathway. Our data suggest that modulation of the sex-shared nervous system by a cascade of neuroendocrine signals can shape sexually dimorphic behaviors.
Volume 7
Published 2018-7-19
DOI 10.7554/eLife.36547
PII 36547
PMID 30024377
PMC PMC6053303
MeSH Animals Behavior, Animal Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / metabolism* Female Gene Expression Regulation* Male Neuropeptides / metabolism* Neurosecretory Systems / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism Sensory Receptor Cells / metabolism* Sex Characteristics* Signal Transduction* Transcription, Genetic
IF 7.551
Times Cited 4
C.elegans tm1996 tm4393