論文 - 詳細
| RRC ID | 56169 |
|---|---|
| 著者 | Hilbert ZA, Kim DH. |
| タイトル | PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans. |
| ジャーナル | Elife |
| Abstract |
Sexually dimorphic behaviors are a feature common to species across the animal kingdom, however how such behaviors are generated from mostly sex-shared nervous systems is not well understood. Building on our previous work which described the sexually dimorphic expression of a neuroendocrine ligand, DAF-7, and its role in behavioral decision-making in C. elegans (Hilbert and Kim, 2017), we show here that sex-specific expression of daf-7 is regulated by another neuroendocrine ligand, Pigment Dispersing Factor (PDF-1), which has previously been implicated in regulating male-specific behavior (Barrios et al., 2012). Our analysis revealed that PDF-1 signaling acts sex- and cell-specifically in the ASJ neurons to regulate the expression of daf-7, and we show that differences in PDFR-1 receptor activity account for the sex-specific effects of this pathway. Our data suggest that modulation of the sex-shared nervous system by a cascade of neuroendocrine signals can shape sexually dimorphic behaviors. |
| 巻・号 | 7 |
| 公開日 | 2018-7-19 |
| DOI | 10.7554/eLife.36547 |
| PII | 36547 |
| PMID | 30024377 |
| PMC | PMC6053303 |
| MeSH | Animals Behavior, Animal Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / metabolism* Female Gene Expression Regulation* Male Neuropeptides / metabolism* Neurosecretory Systems / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism Sensory Receptor Cells / metabolism* Sex Characteristics* Signal Transduction* Transcription, Genetic |
| IF | 7.551 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1996 tm4393 |