論文 - 詳細
| RRC ID | 56177 |
|---|---|
| 著者 | Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV. |
| タイトル | Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. |
| ジャーナル | Virulence |
| Abstract |
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions. |
| 巻・号 | 9(1) |
| ページ | 804-817 |
| 公開日 | 2018-12-31 |
| DOI | 10.1080/21505594.2018.1449508 |
| PMID | 29532717 |
| PMC | PMC5955448 |
| MeSH | Animals Caenorhabditis elegans / microbiology* Host-Pathogen Interactions* Iron / metabolism* Mitochondria / metabolism Mitophagy Oligopeptides / metabolism* Pseudomonas aeruginosa / physiology* Siderophores / metabolism* Virulence Factors / metabolism* |
| IF | 4.775 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1779 |