RRC ID 56177
Author Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV.
Title Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response.
Journal Virulence
Abstract Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.
Volume 9(1)
Pages 804-817
Published 2018-12-31
DOI 10.1080/21505594.2018.1449508
PMID 29532717
PMC PMC5955448
MeSH Animals Caenorhabditis elegans / microbiology* Host-Pathogen Interactions* Iron / metabolism* Mitochondria / metabolism Mitophagy Oligopeptides / metabolism* Pseudomonas aeruginosa / physiology* Siderophores / metabolism* Virulence Factors / metabolism*
IF 4.775
Times Cited 19
C.elegans tm1779