Reference - Detail
| RRC ID | 56266 |
|---|---|
| Author | Hara Y, Arai MA, Toume K, Masu H, Sato T, Komatsu K, Yaguchi T, Ishibashi M. |
| Title | Coculture of a Pathogenic Actinomycete and Animal Cells To Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect. |
| Journal | Org Lett |
| Abstract |
A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects. |
| Volume | 20(18) |
| Pages | 5831-5834 |
| Published | 2018-9-21 |
| DOI | 10.1021/acs.orglett.8b02522 |
| PMID | 30156858 |
| MeSH | Animals Cell Line Cell Survival / drug effects Coculture Techniques* HEK293 Cells Humans Mice Molecular Conformation Nocardia / chemistry Nocardia / growth & development Nocardia / metabolism* Peptides, Cyclic / chemistry Peptides, Cyclic / genetics Peptides, Cyclic / metabolism* Wnt Signaling Pathway / drug effects |
| IF | 6.555 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic eukaryotic microorganisms | 病原放線菌：IFM 10554 |