RRC ID 56499
著者 Davison JR, Bewley CA.
タイトル Antimicrobial Chrysophaentin Analogs Identified from Laboratory Cultures of the Marine Microalga Chrysophaeum taylorii.
ジャーナル J Nat Prod
Abstract A laboratory culture of the colonial marine alga Chrysophaeum taylorii NIES-1699 yielded a set of new bioactive chrysophaentin analogs, and their structures were determined by HRESIMS and NMR spectroscopy. Differences in the metabolites identified between cultured C. taylorii NIES-1699 and field-collected strains from the U.S. Virgin Islands revealed additional structure-activity relationships for the Gram-positive antibiotic activity of the chrysophaentins. The presence of new hemichrysophaentins and a C-C linked biphenyl analog suggest novel features of their biosynthetic pathway. Bayesian analysis of the alignment of the 18S rRNA gene places the microalga C. taylorii in the pelagophyte clade.
巻・号 82(1)
ページ 148-153
公開日 2019-1-25
DOI 10.1021/acs.jnatprod.8b00858
PMID 30623657
PMC PMC8414558
MeSH Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Bayes Theorem Benzyl Compounds Biphenyl Compounds / isolation & purification* Biphenyl Compounds / metabolism Biphenyl Compounds / pharmacology Ethers, Cyclic Marine Biology Microalgae / metabolism* Structure-Activity Relationship
IF 3.885
引用数 3
リソース情報
藻類 NIES-1699