論文 - 詳細
RRC ID | 56499 |
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著者 | Davison JR, Bewley CA. |
タイトル | Antimicrobial Chrysophaentin Analogs Identified from Laboratory Cultures of the Marine Microalga Chrysophaeum taylorii. |
ジャーナル | J Nat Prod |
Abstract |
A laboratory culture of the colonial marine alga Chrysophaeum taylorii NIES-1699 yielded a set of new bioactive chrysophaentin analogs, and their structures were determined by HRESIMS and NMR spectroscopy. Differences in the metabolites identified between cultured C. taylorii NIES-1699 and field-collected strains from the U.S. Virgin Islands revealed additional structure-activity relationships for the Gram-positive antibiotic activity of the chrysophaentins. The presence of new hemichrysophaentins and a C-C linked biphenyl analog suggest novel features of their biosynthetic pathway. Bayesian analysis of the alignment of the 18S rRNA gene places the microalga C. taylorii in the pelagophyte clade. |
巻・号 | 82(1) |
ページ | 148-153 |
公開日 | 2019-1-25 |
DOI | 10.1021/acs.jnatprod.8b00858 |
PMID | 30623657 |
PMC | PMC8414558 |
MeSH | Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Bayes Theorem Benzyl Compounds Biphenyl Compounds / isolation & purification* Biphenyl Compounds / metabolism Biphenyl Compounds / pharmacology Ethers, Cyclic Marine Biology Microalgae / metabolism* Structure-Activity Relationship |
IF | 3.885 |
引用数 | 3 |
リソース情報 | |
藻類 | NIES-1699 |