論文 - 詳細
| RRC ID | 5655 |
|---|---|
| 著者 | Sinenko SA, Mandal L, Martinez-Agosto JA, Banerjee U. |
| タイトル | Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. |
| ジャーナル | Dev Cell |
| Abstract |
In Drosophila, blood development occurs in a specialized larval hematopoietic organ, the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to multiple blood cell types. Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemocytes. Loss- and gain-of-function analysis indicates that canonical Wg signaling is required for maintenance of prohemocytes and negatively regulates their differentiation. Wg signals locally in a short-range fashion within different compartments of the LG. In addition, Wg signaling positively regulates the proliferation and maintenance of cells that function as a hematopoietic niche in Drosophila, the posterior signaling center (PSC), and in the proliferation of crystal cells. Our studies reveal a conserved function of Wg signaling in the maintenance of stem-like blood progenitors and reveal an involvement of this pathway in the regulation of hemocyte differentiation through its action in the hematopoietic niche. |
| 巻・号 | 16(5) |
| ページ | 756-63 |
| 公開日 | 2009-5-1 |
| DOI | 10.1016/j.devcel.2009.03.003 |
| PII | S1534-5807(09)00093-8 |
| PMID | 19460351 |
| PMC | PMC2718753 |
| MeSH | Animals Cell Proliferation Drosophila / embryology* Drosophila Proteins / metabolism* Embryo, Nonmammalian Frizzled Receptors / metabolism Hemocytes / cytology Hemocytes / metabolism* Signal Transduction* Wnt1 Protein / metabolism* |
| IF | 10.092 |
| 引用数 | 81 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
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| 各媒体での言及数の合計 | 0 |
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