RRC ID 56623
Author Su YW, Chim SM, Zhou L, Hassanshahi M, Chung R, Fan C, Song Y, Foster BK, Prestidge CA, Peymanfar Y, Tang Q, Butler LM, Gronthos S, Chen D, Xie Y, Chen L, Zhou XF, Xu J, Xian CJ.
Title Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats.
Journal Bone
Abstract cells. Thus, injury site osteoblast-derived NT-3 is important in promoting growth plate injury site remodelling, as it induces cartilage proteases for cartilage removal and augments osteoclastogenesis and resorption both directly (involving activing Erk1/2 and substantiating RANKL-induced increased expression of osteoclastogenic signals in differentiating osteoclasts) and indirectly (inducing osteoclastogenic signals in osteoblasts).
Volume 116
Pages 232-247
Published 2018-11
DOI 10.1016/j.bone.2018.08.010
PII S8756-3282(18)30316-8
PMID 30125729
PMC PMC6550307
MeSH Animals Bony Callus / metabolism Bony Callus / pathology Cartilage, Articular / pathology* Cytokines / metabolism Enzyme Activation / drug effects Growth Plate / drug effects Growth Plate / metabolism* Growth Plate / pathology* Humans Male Mice NF-kappa B / metabolism NFATC Transcription Factors / metabolism Neurotrophin 3 / metabolism* Osteoblasts / drug effects Osteoblasts / metabolism* Osteoblasts / pathology Osteoclasts / drug effects Osteoclasts / metabolism* Osteogenesis / drug effects Peptide Hydrolases / metabolism* RANK Ligand / pharmacology RAW 264.7 Cells RNA, Messenger / genetics RNA, Messenger / metabolism Rats, Sprague-Dawley Receptor, trkC / metabolism
IF 4.455
Human and Animal Cells RAW 264(RCB0535)