論文 - 詳細
| RRC ID | 56630 |
|---|---|
| 著者 | Seike T, Maekawa H, Nakamura T, Shimoda C. |
| タイトル | The asymmetric chemical structures of two mating pheromones reflect their differential roles in mating of fission yeast. |
| ジャーナル | J Cell Sci |
| Abstract |
In the fission yeast Schizosaccharomyces pombe, the mating reaction is controlled by two mating pheromones, M-factor and P-factor, secreted by M- and P-type cells, respectively. M-factor is a C-terminally farnesylated lipid peptide, whereas P-factor is a simple peptide. To examine whether this chemical asymmetry in the two pheromones is essential for conjugation, we constructed a mating system in which either pheromone can stimulate both M- and P-cells, and examined whether the resulting autocrine strains can mate. Autocrine M-cells responding to M-factor successfully mated with P-factor-lacking P-cells, indicating that P-factor is not essential for conjugation; by contrast, autocrine P-cells responding to P-factor were unable to mate with M-factor-lacking M-cells. The sterility of the autocrine P-cells was completely restored by expressing the M-factor receptor. These observations indicate that the different chemical characteristics of the two types of pheromone, a lipid and a simple peptide, are not essential; however, a lipid peptide might be required for successful mating. Our findings allow us to propose a model of the differential roles of M-factor and P-factor in conjugation of S. pombeThis article has an associated First Person interview with the first author of the paper. |
| 巻・号 | 132(12) |
| 公開日 | 2019-6-25 |
| DOI | 10.1242/jcs.230722 |
| PII | jcs.230722 |
| PMID | 31186279 |
| MeSH | Cell Communication / genetics* DNA-Binding Proteins / metabolism* Gene Expression Regulation, Fungal* Genes, Fungal Peptides / metabolism Pheromones / metabolism* Schizosaccharomyces / genetics Schizosaccharomyces / metabolism* Schizosaccharomyces pombe Proteins / metabolism |
| IF | 4.517 |
| 引用数 | 1 |
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オルトメトリクス指標項目
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| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FY25441(FS65) FY25442(FS66) FY7507(L972) FY7519(L975) |