論文 - 詳細
RRC ID | 56919 |
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著者 | Hamamoto H, Sekimizu K. |
タイトル | [Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model]. |
ジャーナル | Yakugaku Zasshi |
Abstract |
In this symposium, we reported the identification and mechanistic analysis of a novel antibiotic named lysocin E. Lysocin E was identified by screening for therapeutic effectiveness in a silkworm Staphylococcus aureus infection model. The advantages of the silkworm infection model for screening and purification of antibiotics from the culture supernatant of soil bacteria are: 1) low cost; 2) no ethical issues; 3) convenient for evaluation of the therapeutic effectiveness of antibiotics; and 4) pharmacokinetics similar to those of mammals. Lysocin E has remarkable features compared with known antibiotics such as a novel mechanism of action and target. Here, we summarize our reports presented in this symposium. |
巻・号 | 137(4) |
ページ | 389-392 |
公開日 | 2017-1-1 |
DOI | 10.1248/yakushi.16-00235-4 |
PMID | 28381711 |
MeSH | Animals Anti-Bacterial Agents / pharmacokinetics Anti-Bacterial Agents / therapeutic use* Bombyx* Disease Models, Animal* Drug Evaluation, Preclinical / economics* Drug Evaluation, Preclinical / ethics* Peptides, Cyclic / pharmacokinetics Peptides, Cyclic / therapeutic use* Staphylococcal Infections / drug therapy* |
IF | 0.286 |
引用数 | 1 |
リソース情報 | |
カイコ |