RRC ID 56919
著者 Hamamoto H, Sekimizu K.
タイトル [Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model].
ジャーナル Yakugaku Zasshi
Abstract In this symposium, we reported the identification and mechanistic analysis of a novel antibiotic named lysocin E. Lysocin E was identified by screening for therapeutic effectiveness in a silkworm Staphylococcus aureus infection model. The advantages of the silkworm infection model for screening and purification of antibiotics from the culture supernatant of soil bacteria are: 1) low cost; 2) no ethical issues; 3) convenient for evaluation of the therapeutic effectiveness of antibiotics; and 4) pharmacokinetics similar to those of mammals. Lysocin E has remarkable features compared with known antibiotics such as a novel mechanism of action and target. Here, we summarize our reports presented in this symposium.
巻・号 137(4)
ページ 389-392
公開日 2017-1-1
DOI 10.1248/yakushi.16-00235-4
PMID 28381711
MeSH Animals Anti-Bacterial Agents / pharmacokinetics Anti-Bacterial Agents / therapeutic use* Bombyx* Disease Models, Animal* Drug Evaluation, Preclinical / economics* Drug Evaluation, Preclinical / ethics* Peptides, Cyclic / pharmacokinetics Peptides, Cyclic / therapeutic use* Staphylococcal Infections / drug therapy*
IF 0.286
引用数 1
リソース情報
カイコ