| RRC ID |
5693
|
| Author |
Nakayama M, Maruyama S, Kanda H, Ohkita N, Nakano K, Ito F, Kawasaki K.
|
| Title |
Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage.
|
| Journal |
FEBS Lett
|
| Abstract |
Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.
|
| Volume |
580(30)
|
| Pages |
6938-42
|
| Published |
2006-12-22
|
| DOI |
10.1016/j.febslet.2006.11.059
|
| PII |
S0014-5793(06)01400-1
|
| PMID |
17157839
|
| MeSH |
Animals
Cell Cycle*
Cell Line
DNA Damage / genetics*
Drosophila melanogaster / cytology
Drosophila melanogaster / enzymology*
Drosophila melanogaster / genetics*
Eye / cytology
Eye / metabolism
Gene Expression Regulation, Enzymologic
Microscopy, Electron, Scanning
Phenotype
RecQ Helicases / genetics
RecQ Helicases / metabolism*
|
| IF |
3.057
|
| Times Cited |
6
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Drosophila |
DGRC#107531
DGRC#107532 |
