RRC ID 57110
Author Bielopolski N, Amin H, Apostolopoulou AA, Rozenfeld E, Lerner H, Huetteroth W, Lin AC, Parnas M.
Title Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila.
Journal Elife
Abstract Olfactory associative learning in Drosophila is mediated by synaptic plasticity between the Kenyon cells of the mushroom body and their output neurons. Both Kenyon cells and their inputs from projection neurons are cholinergic, yet little is known about the physiological function of muscarinic acetylcholine receptors in learning in adult flies. Here, we show that aversive olfactory learning in adult flies requires type A muscarinic acetylcholine receptors (mAChR-A), particularly in the gamma subtype of Kenyon cells. mAChR-A inhibits odor responses and is localized in Kenyon cell dendrites. Moreover, mAChR-A knockdown impairs the learning-associated depression of odor responses in a mushroom body output neuron. Our results suggest that mAChR-A function in Kenyon cell dendrites is required for synaptic plasticity between Kenyon cells and their output neurons.
Volume 8
Published 2019-6-19
DOI 10.7554/eLife.48264
PII 48264
PMID 31215865
PMC PMC6641838
MeSH Aging / physiology* Animals Behavior, Animal / drug effects Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / cytology Drosophila melanogaster / drug effects Drosophila melanogaster / physiology* Learning* Muscarine / pharmacology Muscarinic Agonists / pharmacology Mushroom Bodies / cytology Mushroom Bodies / drug effects Mushroom Bodies / physiology Mutation / genetics Odorants Receptors, Muscarinic / genetics Receptors, Muscarinic / physiology* Smell / drug effects Smell / physiology*
IF 7.551
Times Cited 3
Drosophila DGRC#104266