RRC ID 57122
Author Yasinskyi Y, O P, O M, V R, Prylutskyy Y, Tauscher E, Ritter U, Kozeretska I.
Title Reconciling the controversial data on the effects of C60 fullerene at the organismal and molecular levels using as a model Drosophila melanogaster.
Journal Toxicol. Lett.
Abstract Fullerenes have attracted attention since their discovery as structural units of complex carbon nanostructures capable of transporting drugs and macromolecules. As such artificial nanomaterials are applied in biology and medicine, they are routinely scrutinized for their effects on living organisms. The results of such studies range from direct destabilizing effects on DNA molecules to amelioration of the toxic effects of known genotoxic agents. We tested the effect of buckminsterfullerene (C60) on Drosophila melanogaster at DNA, tissue and organism levels. The water-soluble pristine C60 fullerene at the concentration of 20 μg/ml and 40 μg/ml leads to the activation of the mus209 gene in D. melanogaster larvae salivary glands, which can indicate higher levels of DNA damage. However, the absence of effects at the cell and organismal level could be explained by the activation of repair systems or by active elimination of damaged cells.
Volume 310
Pages 92-98
Published 2019-8
DOI 10.1016/j.toxlet.2019.03.006
PII S0378-4274(18)31914-3
PMID 30999038
MeSH Animals Animals, Genetically Modified DNA Damage DNA Repair / drug effects Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / drug effects* Drosophila melanogaster / embryology Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Female Fullerenes / toxicity* Male Mutagenicity Tests Nanoparticles / toxicity* Proliferating Cell Nuclear Antigen / genetics Proliferating Cell Nuclear Antigen / metabolism Risk Assessment Salivary Glands / drug effects* Salivary Glands / embryology Salivary Glands / metabolism Transcriptional Activation / drug effects
Resource
Drosophila