論文 - 詳細
| RRC ID | 57130 |
|---|---|
| 著者 | Jagannathan M, Cummings R, Yamashita YM. |
| タイトル | The modular mechanism of chromocenter formation in Drosophila. |
| ジャーナル | Elife |
| Abstract |
A central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. Previously we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known as chromocenters ensures encapsulation of all chromosomes into a single nucleus (Jagannathan et al., 2018). Chromocenter disruption led to micronuclei formation, resulting in cell death. Here we show that chromocenter formation is mediated by a 'modular' network, where associations between two sequence-specific satellite DNA-binding proteins, D1 and Prod, bound to their cognate satellite DNAs, bring the full complement of chromosomes into the chromocenter. D1 prod double mutants die during embryogenesis, exhibiting enhanced phenotypes associated with chromocenter disruption, revealing the universal importance of satellite DNAs and chromocenters. Taken together, we propose that associations between chromocenter modules, consisting of satellite DNA binding proteins and their cognate satellite DNA, package the Drosophila genome within a single nucleus. |
| 巻・号 | 8 |
| 公開日 | 2019-2-11 |
| DOI | 10.7554/eLife.43938 |
| PII | 43938 |
| PMID | 30741633 |
| PMC | PMC6382350 |
| MeSH | Animals Chromosome Structures* DNA, Satellite / genetics Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Genes, Insect Genes, Lethal Male Mutation Spermatocytes / ultrastructure |
| IF | 7.551 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 34 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#140754 DGRC#111248 |