論文 - 詳細
| RRC ID | 57140 |
|---|---|
| 著者 | Hauswirth AG, Ford KJ, Wang T, Fetter RD, Tong A, Davis GW. |
| タイトル | A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity. |
| ジャーナル | Elife |
| Abstract |
Presynaptic homeostatic plasticity stabilizes information transfer at synaptic connections in organisms ranging from insect to human. By analogy with principles of engineering and control theory, the molecular implementation of PHP is thought to require postsynaptic signaling modules that encode homeostatic sensors, a set point, and a controller that regulates transsynaptic negative feedback. The molecular basis for these postsynaptic, homeostatic signaling elements remains unknown. Here, an electrophysiology-based screen of the Drosophila kinome and phosphatome defines a postsynaptic signaling platform that includes a required function for PI3K-cII, PI3K-cIII and the small GTPase Rab11 during the rapid and sustained expression of PHP. We present evidence that PI3K-cII localizes to Golgi-derived, clathrin-positive vesicles and is necessary to generate an endosomal pool of PI(3)P that recruits Rab11 to recycling endosomal membranes. A morphologically distinct subdivision of this platform concentrates postsynaptically where we propose it functions as a homeostatic controller for retrograde, trans-synaptic signaling. |
| 巻・号 | 7 |
| 公開日 | 2018-1-5 |
| DOI | 10.7554/eLife.31535 |
| PII | 31535 |
| PMID | 29303480 |
| PMC | PMC5773188 |
| MeSH | Animals Class II Phosphatidylinositol 3-Kinases / metabolism* Class III Phosphatidylinositol 3-Kinases / metabolism Drosophila Drosophila Proteins / metabolism Electrophysiological Phenomena Neuronal Plasticity* Phosphatidylinositol Phosphates / metabolism Presynaptic Terminals / physiology* Signal Transduction* rab GTP-Binding Proteins / metabolism |
| IF | 7.551 |
| 引用数 | 11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |