| RRC ID |
57160
|
| 著者 |
Astigarraga S, Douthit J, Tarnogorska D, Creamer MS, Mano O, Clark DA, Meinertzhagen IA, Treisman JE.
|
| タイトル |
Drosophila Sidekick is required in developing photoreceptors to enable visual motion detection.
|
| ジャーナル |
Development
|
| Abstract |
The assembly of functional neuronal circuits requires growth cones to extend in defined directions and recognize the correct synaptic partners. Homophilic adhesion between vertebrate Sidekick proteins promotes synapse formation between retinal neurons involved in visual motion detection. We show here that Drosophila Sidekick accumulates in specific synaptic layers of the developing motion detection circuit and is necessary for normal optomotor behavior. Sidekick is required in photoreceptors, but not in their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation. Sidekick is also localized to the dendrites of the direction-selective T4 and T5 cells, and is expressed in some of their presynaptic partners. In contrast to its vertebrate homologs, Sidekick is not essential for T4 and T5 to direct their dendrites to the appropriate layers or to receive synaptic contacts. These results illustrate a conserved requirement for Sidekick proteins in establishing visual motion detection circuits that is achieved through distinct cellular mechanisms in Drosophila and vertebrates.
|
| 巻・号 |
145(3)
|
| 公開日 |
2018-2-5
|
| DOI |
10.1242/dev.158246
|
| PII |
dev.158246
|
| PMID |
29361567
|
| PMC |
PMC5818003
|
| MeSH |
Animals
Animals, Genetically Modified
Drosophila Proteins / genetics
Drosophila Proteins / physiology*
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development*
Drosophila melanogaster / physiology*
Eye Proteins / genetics
Eye Proteins / physiology*
Female
Genes, Insect
Male
Motion Perception / physiology*
Mutation
Neural Cell Adhesion Molecules / genetics
Neural Cell Adhesion Molecules / physiology*
Photoreceptor Cells, Invertebrate / cytology
Photoreceptor Cells, Invertebrate / physiology*
Synapses / metabolism
Visual Pathways / cytology
Visual Pathways / growth & development
Visual Pathways / physiology
|
| IF |
5.763
|
| 引用数 |
5
|
| リソース情報 |
| ショウジョウバエ |
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