論文 - 詳細
| RRC ID | 57192 |
|---|---|
| 著者 | Utashiro N, Williams CR, Parrish JZ, Emoto K. |
| タイトル | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae. |
| ジャーナル | Sci Rep |
| Abstract |
Animal responses to their environment rely on activation of sensory neurons by external stimuli. In many sensory systems, however, neurons display basal activity prior to the external stimuli. This prior activity is thought to modulate neural functions, yet its impact on animal behavior remains elusive. Here, we reveal a potential role for prior activity in olfactory receptor neurons (ORNs) in shaping larval olfactory behavior. We show that prior activity in larval ORNs is mediated by the olfactory receptor complex (OR complex). Mutations of Orco, an odorant co-receptor required for OR complex function, cause reduced attractive behavior in response to optogenetic activation of ORNs. Calcium imaging reveals that Orco mutant ORNs fully respond to optogenetic stimulation but exhibit altered temporal patterns of neural responses. These findings together suggest a critical role for prior activity in information processing upon ORN activation in Drosophila larvae, which in turn contributes to olfactory behavior control. |
| 巻・号 | 8(1) |
| ページ | 8580 |
| 公開日 | 2018-6-5 |
| DOI | 10.1038/s41598-018-26825-3 |
| PII | 10.1038/s41598-018-26825-3 |
| PMID | 29872087 |
| PMC | PMC5988719 |
| MeSH | Animals Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Drosophila melanogaster / physiology* Larva / genetics Larva / metabolism Larva / physiology Mutation Odorants Olfactory Pathways / metabolism Olfactory Pathways / physiology* Olfactory Receptor Neurons / metabolism Olfactory Receptor Neurons / physiology* Optogenetics / methods Receptors, Odorant / genetics Receptors, Odorant / physiology* Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology* Smell / physiology* |
| IF | 4.011 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |