論文 - 詳細
| RRC ID | 57202 |
|---|---|
| 著者 | Forest E, Logeay R, Géminard C, Kantar D, Frayssinoux F, Heron-Milhavet L, Djiane A. |
| タイトル | The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs. |
| ジャーナル | J Cell Biol |
| Abstract |
During development, cell numbers are tightly regulated, ensuring that tissues and organs reach their correct size and shape. Recent evidence has highlighted the intricate connections between the cytoskeleton and the regulation of the key growth control Hippo pathway. Looking for apical scaffolds regulating tissue growth, we describe that Drosophila melanogaster big bang (Bbg), a poorly characterized multi-PDZ scaffold, controls epithelial tissue growth without affecting epithelial polarity and architecture. bbg-mutant tissues are smaller, with fewer cells that are less apically constricted than normal. We show that Bbg binds to and colocalizes tightly with the β-heavy-Spectrin/Kst subunit at the apical cortex and promotes Yki activity, F-actin enrichment, and the phosphorylation of the myosin II regulatory light chain Spaghetti squash. We propose a model in which the spectrin cytoskeleton recruits Bbg to the cortex, where Bbg promotes actomyosin contractility to regulate epithelial tissue growth. |
| 巻・号 | 217(3) |
| ページ | 1047-1062 |
| 公開日 | 2018-3-5 |
| DOI | 10.1083/jcb.201705107 |
| PII | jcb.201705107 |
| PMID | 29326287 |
| PMC | PMC5839784 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Imaginal Discs / cytology Imaginal Discs / embryology* Models, Biological* Mutation* Wings, Animal / cytology Wings, Animal / embryology* |
| IF | 8.891 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 44 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |