論文 - 詳細
| RRC ID | 57250 |
|---|---|
| 著者 | Chiang AC, Yang H, Yamashita YM. |
| タイトル | spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis. |
| ジャーナル | Sci Rep |
| Abstract |
Tissues are maintained in a homeostatic state by balancing the constant loss of old cells with the continued production of new cells. Tissue homeostasis can shift between high and low turnover states to cope with environmental changes such as nutrient availability. Recently, we discovered that the elimination of transit-amplifying cells plays a critical role in maintaining the stem cell population during protein starvation in the Drosophila testis. Here, we identify spict, a gene expressed specifically in differentiating cyst cells, as a regulator of spermatogonial death. Spict is upregulated in cyst cells that phagocytose dying spermatogonia. We propose that phagocytosis and subsequent clearance of dead spermatogonia, which is partly promoted by Spict, contribute to stem cell maintenance during prolonged protein starvation. |
| 巻・号 | 7 |
| ページ | 40245 |
| 公開日 | 2017-1-10 |
| DOI | 10.1038/srep40245 |
| PII | srep40245 |
| PMID | 28071722 |
| PMC | PMC5223112 |
| MeSH | Animals Cell Death* Cell Differentiation Cysts / genetics* Drosophila Drosophila Proteins / genetics* Drosophila Proteins / physiology Male Membrane Proteins / genetics* Membrane Proteins / physiology Phagocytosis Spermatogonia / physiology* Starvation / physiopathology* Testis / physiology* |
| IF | 4.011 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |