論文 - 詳細
| RRC ID | 57253 |
|---|---|
| 著者 | Chowdhury ZS, Sato K, Yamamoto D. |
| タイトル | The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila. |
| ジャーナル | Nat Commun |
| Abstract |
In fruit flies, the male-specific fruitless (fru) gene product FruBM plays a central role in establishing the neural circuitry for male courtship behavior by orchestrating the transcription of genes required for the male-type specification of individual neurons. We herein identify the core promoter recognition factor gene Trf2 as a dominant modifier of fru actions. Trf2 knockdown in the sexually dimorphic mAL neurons leads to the loss of a male-specific neurite and a reduction in male courtship vigor. TRF2 forms a repressor complex with FruBM, strongly enhancing the repressor activity of FruBM at the promoter region of the robo1 gene, whose function is required for inhibiting the male-specific neurite formation. In females that lack FruBM, TRF2 stimulates robo1 transcription. Our results suggest that TRF2 switches its own role from an activator to a repressor of transcription upon binding to FruBM, thereby enabling the ipsilateral neurite formation only in males. |
| 巻・号 | 8(1) |
| ページ | 1480 |
| 公開日 | 2017-11-14 |
| DOI | 10.1038/s41467-017-01623-z |
| PII | 10.1038/s41467-017-01623-z |
| PMID | 29133872 |
| PMC | PMC5684138 |
| MeSH | Animals Courtship Drosophila Proteins / physiology* Drosophila melanogaster / physiology* Female Gene Knockdown Techniques Male Nerve Net / physiology Nerve Tissue Proteins / genetics Nerve Tissue Proteins / physiology* Neurites / physiology Promoter Regions, Genetic / genetics Receptors, Immunologic / genetics Repressor Proteins / physiology Sex Characteristics* Sexual Behavior, Animal / physiology* Telomeric Repeat Binding Protein 2 / physiology* Transcription Factors / physiology* Transcription, Genetic / physiology Transcriptional Activation / physiology |
| IF | 11.878 |
| 引用数 | 5 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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