| RRC ID |
57253
|
| 著者 |
Chowdhury ZS, Sato K, Yamamoto D.
|
| タイトル |
The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila.
|
| ジャーナル |
Nat Commun
|
| Abstract |
In fruit flies, the male-specific fruitless (fru) gene product FruBM plays a central role in establishing the neural circuitry for male courtship behavior by orchestrating the transcription of genes required for the male-type specification of individual neurons. We herein identify the core promoter recognition factor gene Trf2 as a dominant modifier of fru actions. Trf2 knockdown in the sexually dimorphic mAL neurons leads to the loss of a male-specific neurite and a reduction in male courtship vigor. TRF2 forms a repressor complex with FruBM, strongly enhancing the repressor activity of FruBM at the promoter region of the robo1 gene, whose function is required for inhibiting the male-specific neurite formation. In females that lack FruBM, TRF2 stimulates robo1 transcription. Our results suggest that TRF2 switches its own role from an activator to a repressor of transcription upon binding to FruBM, thereby enabling the ipsilateral neurite formation only in males.
|
| 巻・号 |
8(1)
|
| ページ |
1480
|
| 公開日 |
2017-11-14
|
| DOI |
10.1038/s41467-017-01623-z
|
| PII |
10.1038/s41467-017-01623-z
|
| PMID |
29133872
|
| PMC |
PMC5684138
|
| MeSH |
Animals
Courtship
Drosophila Proteins / physiology*
Drosophila melanogaster / physiology*
Female
Gene Knockdown Techniques
Male
Nerve Net / physiology
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / physiology*
Neurites / physiology
Promoter Regions, Genetic / genetics
Receptors, Immunologic / genetics
Repressor Proteins / physiology
Sex Characteristics*
Sexual Behavior, Animal / physiology*
Telomeric Repeat Binding Protein 2 / physiology*
Transcription Factors / physiology*
Transcription, Genetic / physiology
Transcriptional Activation / physiology
|
| IF |
11.878
|
| 引用数 |
5
|
| リソース情報 |
| ショウジョウバエ |
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