論文 - 詳細
| RRC ID | 57272 |
|---|---|
| 著者 | Mohammad F, Stewart JC, Ott S, Chlebikova K, Chua JY, Koh TW, Ho J, Claridge-Chang A. |
| タイトル | Optogenetic inhibition of behavior with anion channelrhodopsins. |
| ジャーナル | Nat Methods |
| Abstract |
Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior. |
| 巻・号 | 14(3) |
| ページ | 271-274 |
| 公開日 | 2017-3-1 |
| DOI | 10.1038/nmeth.4148 |
| PII | nmeth.4148 |
| PMID | 28114289 |
| MeSH | Action Potentials / physiology Animals Behavior, Animal / drug effects* Behavior, Animal / physiology Drosophila / physiology* Light Locomotion / physiology Neural Pathways / physiology* Neurons / physiology Optogenetics / methods* Organisms, Genetically Modified Rhodopsin / pharmacology* Taste Perception / physiology Voltage-Dependent Anion Channels / physiology |
| IF | 28.467 |
| 引用数 | 50 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 43 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |