| RRC ID |
57272
|
| 著者 |
Mohammad F, Stewart JC, Ott S, Chlebikova K, Chua JY, Koh TW, Ho J, Claridge-Chang A.
|
| タイトル |
Optogenetic inhibition of behavior with anion channelrhodopsins.
|
| ジャーナル |
Nat Methods
|
| Abstract |
Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior.
|
| 巻・号 |
14(3)
|
| ページ |
271-274
|
| 公開日 |
2017-3-1
|
| DOI |
10.1038/nmeth.4148
|
| PII |
nmeth.4148
|
| PMID |
28114289
|
| MeSH |
Action Potentials / physiology
Animals
Behavior, Animal / drug effects*
Behavior, Animal / physiology
Drosophila / physiology*
Light
Locomotion / physiology
Neural Pathways / physiology*
Neurons / physiology
Optogenetics / methods*
Organisms, Genetically Modified
Rhodopsin / pharmacology*
Taste Perception / physiology
Voltage-Dependent Anion Channels / physiology
|
| IF |
28.467
|
| 引用数 |
50
|
| リソース情報 |
| ショウジョウバエ |
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