論文 - 詳細
| RRC ID | 57288 |
|---|---|
| 著者 | Tokusumi T, Tokusumi Y, Schulz RA. |
| タイトル | The mir-7 and bag of marbles genes regulate Hedgehog pathway signaling in blood cell progenitors in Drosophila larval lymph glands. |
| ジャーナル | Genesis |
| Abstract |
Hedgehog (Hh) pathway signaling is crucial for the maintenance of blood cell progenitors in the lymph gland hematopoietic organ present in Drosophila third instar larvae. Previous studies from our lab have likewise shown the importance of the mir-7 and bag of marbles (bam) genes in maintaining the progenitor state. Thus, we sought to investigate a possible interaction between the Hh pathway and mir-7/bam in the prohemocyte population within this hematopoietic tissue. Gain of function mir-7 was able to rescue a blood cell progenitor depletion phenotype caused by Patched (Ptc) inhibition of Hh pathway signaling in these cells. Similarly, expression of a dominant/negative version of Ptc was able to rescue the severe reduction of prohemocytes due to bam loss of function. Furthermore, we demonstrated that Suppressor of fused [Su(fu)], another known inhibitor of Hh signaling, likely serves as a translational repression target of the mir-7 miRNA. Our results suggest the mir-7/bam combination regulates the Hh signaling network through repression of Su(fu) to maintain hemocyte progenitors in the larval lymph gland. |
| 巻・号 | 56(5) |
| ページ | e23210 |
| 公開日 | 2018-5-1 |
| DOI | 10.1002/dvg.23210 |
| PMID | 29663653 |
| PMC | PMC5980778 |
| MeSH | Animals Blood Cells Cell Differentiation / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental / genetics Hedgehog Proteins / genetics Hematopoietic Stem Cells / metabolism Larva / metabolism Lymph Nodes / embryology Lymph Nodes / metabolism MicroRNAs / genetics MicroRNAs / metabolism* Receptors, Immunologic / metabolism Repressor Proteins / genetics Signal Transduction |
| IF | 1.74 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105442 |