論文 - 詳細
| RRC ID | 57429 |
|---|---|
| 著者 | Yang S, Zhao Y, Yu J, Fan Z, Gong ST, Tang H, Pan L. |
| タイトル | Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila. |
| ジャーナル | Cell Host Microbe |
| Abstract |
Interorgan immunological communication is critical to connect the local-systemic innate immune response and orchestrate a homeostatic host defense. However, the factors and their roles in this process remain unclear. We find Drosophila IMD response in guts can sequentially trigger a systemic IMD reaction in the fat body. Sugar alcohols of the polyol pathway are essential for the spatiotemporal regulation of gut-fat body immunological communication (GFIC). IMD activation in guts causes elevated levels of sorbitol and galactitol in hemolymph. Aldose reductase (AR) in hemocytes, the rate-limiting enzyme of the polyol pathway, is necessary and sufficient for the increase of plasma sugar alcohols. Sorbitol relays GFIC by subsequent activation of Metalloprotease 2, which cleaves PGRP-LC to activate IMD response in fat bodies. Thus, this work unveils how GFIC relies on the intermediate activation of the polyol pathway in hemolymph and demonstrates that AR provides a critical metabolic checkpoint in the global inflammatory response. |
| 巻・号 | 26(2) |
| ページ | 240-251.e8 |
| 公開日 | 2019-8-14 |
| DOI | 10.1016/j.chom.2019.07.001 |
| PII | S1931-3128(19)30345-2 |
| PMID | 31350199 |
| MeSH | Alarmins / immunology* Aldehyde Reductase / genetics Aldehyde Reductase / metabolism Aldo-Keto Reductases / genetics Animals Animals, Genetically Modified Carrier Proteins / metabolism Drosophila / genetics Drosophila / immunology* Fat Body / metabolism Galactitol / blood Galactitol / metabolism Hemolymph / metabolism Humans Immunity, Innate / physiology* Inflammation / immunology Male Metalloproteases / metabolism Polymers / metabolism* Signal Transduction / immunology Sorbitol / blood Sorbitol / metabolism Sugar Alcohols / blood Sugar Alcohols / metabolism* |
| IF | 15.753 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 11992R-1 11992R-2 6084R-1 6084R-3 |