論文 - 詳細
| RRC ID | 57671 |
|---|---|
| 著者 | Kojima N, Yoshida Y, Kurosawa N, Lee YC, Tsuji S. |
| タイトル | Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence for alpha 2,8-sialyltransferase activity toward N-linked oligosaccharides. |
| ジャーナル | FEBS Lett |
| Abstract |
We have detected sialyltransferase activity of recombinant mouse STX, which was cloned from rat brain as a new member of the sialyltransferase family, but sialyltransferase activity of which had not been detected previously [Livingston and Paulson, J. Biol. Chem. (1993) 268, 11504-11507]. The activity of mouse STX was specific toward sialylated glycoproteins. N-Glycanase treatment and linkage-specific sialidase treatment of glycoproteins revealed that STX transfers sialic acids through alpha 2,8-linkages to only N-linked oligosaccharides of glycoproteins. However, polymerase activity for polysialic acid synthesis was not detected for this sialyltransferase. Since this alpha 2,8-sialyltransferase gene is highly restricted in fetal and newborn brain, it may be involved in the polysialylation of glycoproteins, especially of N-CAM. |
| 巻・号 | 360(1) |
| ページ | 1-4 |
| 公開日 | 1995-2-20 |
| DOI | 10.1016/0014-5793(95)00059-i |
| PII | 0014-5793(95)00059-I |
| PMID | 7875291 |
| MeSH | Animals Base Sequence Cloning, Molecular DNA, Complementary Gene Expression Regulation, Enzymologic* Mice Molecular Sequence Data Oligosaccharides / metabolism* Sialyltransferases / genetics Sialyltransferases / metabolism* |
| IF | 3.057 |
| 引用数 | 104 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | mST8SiaII (RDB02078) |