RRC ID 57731
著者 Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.
タイトル Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells.
ジャーナル J Biochem
Abstract Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.
巻・号 166(2)
ページ 163-173
公開日 2019-8-1
DOI 10.1093/jb/mvz024
PII 5421174
PMID 30918974
MeSH Autoantigens / genetics Autoantigens / metabolism* Carcinoma, Squamous Cell / metabolism* Carcinoma, Squamous Cell / pathology Cell Line, Tumor Humans MicroRNAs / metabolism* Mouth Neoplasms / metabolism* Mouth Neoplasms / pathology Non-Fibrillar Collagens / genetics Non-Fibrillar Collagens / metabolism* Polymerase Chain Reaction Tumor Suppressor Protein p53 / metabolism
IF 2.476
引用数 1
リソース情報
ヒト・動物細胞 SAS(RCB1974) Ca9-22(RCB1976) Sa3(RCB0980) A431