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  • Search Condition : Filter (MeSH = Tumor Suppressor Protein p53 / metabolism)
Species Resource
DNA material AxCALacZ (RDB1745) Effect of an adenoviral vector that expresses the canine p53 gene on cell growth of canine osteosarcoma and mammary adenocarcinoma cell lines.
C.elegans tm853 Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.
DNA material pcDNA3-XPF (RDB01785) Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.
C.elegans tm470 , tm2384 , tm2178 Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.
C.elegans tm853 C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
Mice C57BL-p53+/- 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain.
DNA material , Mice pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells.
Zebrafish T2KSAG? Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
C.elegans The tumour suppressor CYLD regulates the p53 DNA damage response.
Mice B6;129-Atg5<tm1Nmz>(RBRC02231) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.
DNA material pFLAG-CMV-5a-RPL5 (RDB17329) , pFLAG-CMV-5a-RPL11 (RDB17330) GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
DNA material pNF-kappaB RE-TK hRluc(F) (RDB05576) , pGL4-phTP53 (RDB07330) , pCMFlag_hsTP53 (RDB06754) , pCMV_S-FLAG (RDB05956). NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.
Drosophila 11859R-2 , 3608R-1 , 1954R-1 , 2829R-1 , 32134R-2 p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion.
C.elegans tm1458 A Defective Meiotic Outcome of a Failure in Homologous Pairing and Synapsis Is Masked by Meiotic Quality Control.
C.elegans tm2176 ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
Mice C57BL-p53+/-(RBRC01361) N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change.
Mice 129S6/SvEvTac-Dkk3<tm1Tfur>(RBRC02847) Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
Silkworms Cell proliferation by silk gut incorporating FGF-2 protein microcrystals.
Drosophila Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila.
Medaka p53(E241x) MT894 Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish.