RRC ID 57880
著者 Yamada H, Hakozaki M, Uemura A, Yamashita T.
タイトル Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells.
ジャーナル J Lipid Res
Abstract Fatty acids have various physiological effects on melanoma. For example, palmitic acid (PA) increases melanin levels; linoleic acid and DHA decrease melanin levels; and DHA suppresses tumor growth. In this study, we focused on the relationship between the structure of fatty acids and their physiological effects in melanoma to examine the likely mechanisms of action. We showed that saturated fatty acids and PUFAs display opposing effects on melanin content in melanoma cells. Likewise, PA and EPA have opposing effects in terms of actin polymerization. Our findings suggest that PA and EPA change melanin content in melanoma to alter melanosome trafficking by modulating actin polymerization. Here, we also examined the mechanism of the anti-tumor effect of DHA. We found that DHA interacts with receptor for activated C kinase 1 and represses melanoma cell proliferation by suppressing protein kinase C signaling. Our results suggest a new mechanism to explain the physiological effects of fatty acids.
巻・号 60(9)
ページ 1491-1502
公開日 2019-9-1
DOI 10.1194/jlr.M090712
PII S0022-2275(20)32313-0
PMID 31345992
PMC PMC6718436
MeSH Actins / metabolism Animals Cell Line, Tumor Cell Proliferation / drug effects Dihydroxyphenylalanine / metabolism Docosahexaenoic Acids / pharmacology* Eicosapentaenoic Acid / pharmacology* Fatty Acids / pharmacology* Humans Melanins / metabolism Melanoma / metabolism* Mice Signal Transduction / drug effects
IF 4.483
引用数 1
リソース情報
ヒト・動物細胞 B16F10(RCB2630) COLO 679(RCB0989) G-361(RCB0991) HOMM(RCB1513) HTMM(RCB0700)