RRC ID 58044
著者 Shoji M, Ueda M, Nishioka M, Minato H, Seki M, Harada K, Kubo M, Fukuyama Y, Suzuki Y, Aoyama E, Takigawa M, Kuzuhara T.
タイトル Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells.
ジャーナル Biochem Biophys Res Commun
Abstract Jiadifenolide has been reported to have neurotrophin-like activity in primary rat cortical neurons, and also possesses neurotrophic effects in neuronal precursor cells derived from human induced pluripotent stem cells (hiPSCs), as we have previously reported. However, the molecular mechanisms by which jiadifenolide exerts its neurotrophic effects in rat and human neurons are unknown. Thus, we aimed to investigate the molecular mechanisms and pathways by which jiadifenolide promotes neurotrophic effects. Here, we found that jiadifenolide activated cellular communication network factor (CCN) signaling pathways by up-regulating mRNA level expression of CCN genes in human neuronal cells. We also found that CCN2 (also known as connective tissue growth factor, CTGF) protein promotes neurotrophic effects through activation of the p44/42 mitogen-activated protein kinase signaling pathway. This is the first discovery which links neurotrophic activity with CCN signaling.
巻・号 519(2)
ページ 309-315
公開日 2019-11-5
DOI 10.1016/j.bbrc.2019.09.003
PII S0006-291X(19)31708-5
PMID 31506177
MeSH Brain-Derived Neurotrophic Factor / metabolism* Cells, Cultured Connective Tissue Growth Factor / biosynthesis* Connective Tissue Growth Factor / genetics Humans Induced Pluripotent Stem Cells / drug effects* Induced Pluripotent Stem Cells / metabolism Sesquiterpenes / chemical synthesis Sesquiterpenes / chemistry Sesquiterpenes / pharmacology*
IF 2.985
引用数 1
リソース情報
ヒト・動物細胞 201B7(HPS0063)