Reference - Detail
| RRC ID | 58212 |
|---|---|
| Author | Watanabe K, Kanaoka Y, Mizutani S, Uchiyama H, Yajima S, Watada M, Uemura T, Hattori Y. |
| Title | Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species. |
| Journal | Cell Rep |
| Abstract |
During evolution, organisms have acquired variable feeding habits. Some species are nutritional generalists that adapt to various food resources, while others are specialists, feeding on specific resources. However, much remains to be discovered about how generalists adapt to diversified diets. We find that larvae of the generalists Drosophila melanogaster and D. simulans develop on three diets with different nutrient balances, whereas specialists D. sechellia and D. elegans cannot develop on carbohydrate-rich diets. The generalist D. melanogaster downregulates the expression of diverse metabolic genes systemically by transforming growth factor β (TGF-β)/Activin signaling, maintains metabolic homeostasis, and successfully adapts to the diets. In contrast, the specialist D. sechellia expresses those metabolic genes at higher levels and accumulates various metabolites on the carbohydrate-rich diet, culminating in reduced adaptation. Phenotypic similarities and differences strongly suggest that the robust carbohydrate-responsive regulatory systems are evolutionarily retained through genome-environment interactions in the generalists and contribute to their nutritional adaptabilities. |
| Volume | 28(10) |
| Pages | 2594-2607.e7 |
| Published | 2019-9-3 |
| DOI | 10.1016/j.celrep.2019.08.030 |
| PII | S2211-1247(19)31064-2 |
| PMID | 31484071 |
| MeSH | Adaptation, Physiological / genetics Animals Carbohydrate Metabolism* / genetics Diet Drosophila / genetics Drosophila / metabolism* Food Gene Expression Regulation Metabolome Mutation / genetics Species Specificity |
| IF | 8.109 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 48 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | E-10002 HK0461.03 K-S05 K-S10 K-S02 |