論文 - 詳細
| RRC ID | 58237 |
|---|---|
| 著者 | Nakamura S, Hira S, Fujiwara M, Miyagata N, Tsuji T, Kondo A, Kimura H, Shinozuka Y, Hayashi M, Kobayashi S, Mukai M. |
| タイトル | A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos. |
| ジャーナル | Commun Biol |
| Abstract |
Expression of the vasa gene is associated with germline establishment. Therefore, identification of vasa activator(s) should provide insights into germline development. However, the genes sufficient for vasa activation remain unknown. Previously, we showed that the BTB/POZ-Zn-finger protein Mamo is necessary for vasa expression in Drosophila. Here, we show that the truncated Mamo lacking the BTB/POZ domain (MamoAF) is a potent vasa activator. Overexpression of MamoAF was sufficient to induce vasa expression in both primordial germ cells and brain. Indeed, Mamo mRNA encoding a truncated Mamo isoform, which is similar to MamoAF, was predominantly expressed in primordial germ cells. The results of our genetic and biochemical studies showed that MamoAF, together with CBP, epigenetically activates vasa expression. Furthermore, MamoAF and the germline transcriptional activator OvoB exhibited synergy in activating vasa transcription. We propose that a Mamo-mediated network of epigenetic and transcriptional regulators activates vasa expression. |
| 巻・号 | 2 |
| ページ | 422 |
| 公開日 | 2019-11-20 |
| DOI | 10.1038/s42003-019-0663-4 |
| PII | 663 |
| PMID | 31799425 |
| PMC | PMC6868150 |
| MeSH | Animals DNA-Binding Proteins / genetics* DNA-Binding Proteins / metabolism Drosophila / embryology* Drosophila / genetics* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Embryonic Development / genetics* Epigenesis, Genetic Gene Expression Regulation, Developmental Models, Biological Phenotype Sequence Deletion* Transcription Factors / genetics* Transcription Factors / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109612 |