RRC ID |
58240
|
著者 |
Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G, Igaki T.
|
タイトル |
JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells.
|
ジャーナル |
Sci Rep
|
Abstract |
Multicellular organisms repair injured epithelium by evolutionarily conserved biological processes including activation of c-Jun N-terminal kinase (JNK) signaling. Here, we show in Drosophila imaginal epithelium that physical injury leads to the emergence of dying cells, which are extruded from the wounded tissue by JNK-induced Slit-Roundabout2 (Robo2) repulsive signaling. Reducing Slit-Robo2 signaling in the wounded tissue suppresses extrusion of dying cells and generates aberrant cells with highly upregulated growth factors Wingless (Wg) and Decapentaplegic (Dpp). The inappropriately elevated Wg and Dpp impairs wound repair, as halving one of these growth factor genes cancelled wound healing defects caused by Slit-Robo2 downregulation. Our data suggest that JNK-mediated Slit-Robo2 signaling contributes to epithelial wound repair by promoting extrusion of dying cells from the wounded tissue, which facilitates transient and appropriate induction of growth factors for proper wound healing.
|
巻・号 |
9(1)
|
ページ |
19549
|
公開日 |
2019-12-20
|
DOI |
10.1038/s41598-019-56137-z
|
PII |
10.1038/s41598-019-56137-z
|
PMID |
31863086
|
PMC |
PMC6925126
|
MeSH |
Animals
Drosophila / genetics
Drosophila / metabolism*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
JNK Mitogen-Activated Protein Kinases / genetics
JNK Mitogen-Activated Protein Kinases / metabolism*
Receptors, Immunologic / genetics
Receptors, Immunologic / metabolism
Signal Transduction / physiology*
Wnt1 Protein / genetics
Wnt1 Protein / metabolism
Wound Healing / genetics
Wound Healing / physiology
|
IF |
3.998
|
引用数 |
0
|
リソース情報 |
ショウジョウバエ |
5680R-2
DGRC#106948
DGRC#106843
DGRC#106646
DGRC#106649 |